OnTarget: an agentic AI co-pilot for drug discovery
Built in partnership with In Your Genes Consulting, OnTarget integrates dozens of biomedical data sources into a single LLM-orchestrated workflow — turning weeks of cross-source evidence assembly into minutes.
The Client
In Your Genes Consulting
A scientific consultancy led by a PhD geneticist with 15+ years of publishing experience, specializing in early drug discovery, GWAS meta-analysis, and Mendelian randomization for biomedical clients.
inyourgenesconsulting.netThe Challenge
Drug discovery is data-rich — and bottlenecked by manual synthesis.
Scientists were spending hours querying PubMed, Open Targets, ClinVar, GTEx, ClinicalTrials and a dozen other sources for every hypothesis — then manually stitching the evidence into briefs and slides. Each new question restarted the cycle.
In Your Genes Consulting needed a system that could let scientists ask high-level questions and have an agent execute the underlying multi-source workflow, with full traceability back to every citation.
The Solution
An LLM-powered agent that talks to the entire biomedical stack.
We designed and built OnTarget around four core principles. Scientists describe the question; the agent plans, retrieves, synthesizes, and cites.
Tool-integrated agents
Secure connectors to dozens of biomedical APIs and internal data sources.
LLM planning & orchestration
Goals are decomposed into multi-step plans the agent executes and validates.
Evidence-grounded outputs
Every claim is linked back to its source — no hallucinated citations.
Governed execution
Human-in-the-loop approval gates for sensitive or irreversible actions.
Integration Coverage
One agent. Dozens of authoritative biomedical sources.
OnTarget combines public and proprietary data into repeatable workflows — not one-source-at-a-time lookups.
Literature & Evidence
Targets & Disease
Genetics & Variation
Pathways & Function
Expression & Structure
Clinical Landscape
Agentic Workflows
Repeatable workflows, transparent reasoning.
Four core workflows the OnTarget agent executes end-to-end.
Target Triage & Prioritization
Start from a gene or disease hypothesis. The agent pulls target–disease associations, expression context, human genetics support, and pathway links — then scores target suitability with transparent source traces.
Variant & Mechanism Deep Dive
Gather known variants and clinical significance, cross-reference structural and functional evidence, and generate a mechanism-focused summary with linked references.
Competitive & Clinical Landscape
Retrieve relevant trials and therapeutic programs. Summarize modality, phase, inclusion patterns, and endpoints into a concise landscape report for portfolio decisions.
Research Brief Generation
Compile literature, target biology, genetics, and phenotype evidence into a decision-ready report or slide narrative — with approval checkpoints before finalization.
The Outcome
From manual stitching to a governed discovery co-pilot.
OnTarget shipped as a working agentic platform that In Your Genes Consulting now operates and extends. True to our model, the codebase, runbooks, and operating knowledge live with the client.
- Faster hypothesis-to-insight cycles for the consulting team
- Consistent, source-traced evidence synthesis across programs
- Reproducible, auditable decision support for client engagements
- A scalable operating model from exploratory research to portfolio review
Could this work for you?
The OnTarget pattern applies far beyond drug discovery.
Explore how the same agentic approach can power your team.